NPM is dood, leve NPM!
نویسندگان
چکیده
منابع مشابه
TPL2-NPM-p53 pathway monitors nucleolar stress
Serving as the cellular factory for the biogenesis of ribosomes (the molecular machines responsible for the decoding of mRNAs to proteins), the nucleolus controls a vast array of physiological processes including cell growth and proliferation. It thus comes as no surprise that inherited and acquired abnormalities in ribosome biogenesis can lead to tumorigenesis and that changes in size and numb...
متن کاملMutual Regulation of FOXM1, NPM and ARF Proteins
ARF, NPM and FOXM1 proteins interact with each other in mammalian cells. We showed previously that proteasome inhibitors suppress not only FOXM1 expression, but also the expression of ARF and NPM proteins. Using RNA interference we found that the depletion of each of these proteins by RNAi in human cancer HeLa cells leads to down-regulation of the two other partners, suggesting that these prote...
متن کاملNucleophosmin (NPM) gene rearrangements in Ki-1-positive lymphomas.
The (2;5)(p23;q35) translocation which results in the fusion of the NPM (nucleophosmin) gene on chromosome 5q35 with the novel ALK (anaplastic lymphoma kinase) gene on chromosome 2p23 [S.W. Morris et al., Science (Washington DC), 263: 1281-1284, 1994] is associated with Ki-1 (CD30)-positive anaplastic large cell lymphomas (ALCL); a group of morphologically and immunophenotypically heterogenous ...
متن کاملLymphomas ) Gene Rearrangements in Ki - 1 - positive NPM
The (2;5)(p23;q35) translocation which results in the fusion ofthe NPM (nucleophosmin) gene on chromosome 5q35 with the novelALK (anaplas tic lymphoma kinase) gene on chromosome 2p23 [S.W. Morris et aI, Science (Washington DC), 263: 1281-1284, 1994] is associated with lU-i (CD3O)-posltlve anaplastic large cell lymphomas (ALCL); a group of morphologicaHy and Immunophenotypically heterogenous hig...
متن کاملExtrinsic apoptosis is impeded by direct binding of the APL fusion protein NPM-RAR to TRADD.
UNLABELLED A subset of acute promyelocytic leukemia (APL) cases has been characterized by the t(5;17)(q35;q21) translocation variant, which fuses nucleophosmin (NPM) to retinoic acid receptor α (RARA). The resultant NPM-RAR fusion protein blocks myeloid differentiation and leads to a leukemic phenotype similar to that caused by the t(15;17)(q22;q21) PML-RAR fusion. The contribution of the N-ter...
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ژورنال
عنوان ژورنال: Maandblad Voor Accountancy en Bedrijfseconomie
سال: 2006
ISSN: 2543-1684,0924-6304
DOI: 10.5117/mab.80.12803